Fragile-X syndrome (or FXS) is an inherited syndrome that is caused by a mutation in the X chromosome, causing intellectual disabilities. FXS is one of the most common inherited cause for intellectual disabilities. An individual with Fragile-X syndrome does not have any distinct physical abnormalities in childhood, although there may be subtle physical abnormalities in affected individuals that develop later in adulthood, specifically when the individual reaches puberty. In many cases, Fragile-X syndrome commonly occurs with traits of autism. Although FXS is predominantly found in males. It is less commonly inherited by female.

According to the Centre of Disease Control and Prevention, the early signs to watch for are:

• Learning disabilities.
• Difficulties with short-term memory.
• Difficulties learning skills like walking.
• Difficulties with language and speech.
• Traits of autism.
• Traits of Attention Deficit Hyperactivity Disorder.

Although there is no cure for Fragile-X Syndrome, studies have shown that intensive therapy early in a child’s life, before their brain has fully developed, are crucial in order to fully identify and strengthen the range of intellectual and physical abilities in individuals with Fragile-X Syndrome. SMILE provides a wide variety of therapies that will help optimize a child’s life as they live with Fragile-X syndrome, including occupational therapy, physical therapy, and speech language and pathology therapy. Fragile-X affects individuals in a variety of ways, which is why SMILE stresses the importance of customizing services provided to individuals with Fragile-X syndrome in order to meet their unique needs.